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在衰老C中失去远端-近端GLP-1/Notch激活梯度. 优雅的生长线

Rustelle Janse van Vuuren1,2, Pier-Olivier Martel1,2, Patrick Narbonne1,2

  • 1Département de Biologie Médicale, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada.

microPublication biology
|January 5, 2026
PubMed
概括

No abstract available in PubMed .

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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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