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利用压电刺激调节PI3K-AKT信号来进行椎间盘再生

Yisi Liu1, Jie Hu1, Yu Qian2,3

  • 1Medical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, PR China.

Bioactive materials
|January 5, 2026
PubMed
概括

No abstract available in PubMed .

关键词:
生物电气组织再生固定电荷密度椎间盘退化PI3K-Akt信号通道压电脚手架

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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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