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Updated: Jan 7, 2026

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

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将高度减弱的IL-18定位为PD-1以增强抗瘤活性

Xueyuan Zhou¹, Felix Klaus Geyer², Jeffrey Takimoto¹

¹Drug Discovery and Development, Fuse Biotherapeutics, Woburn, MA, United States.

Frontiers in immunology

|January 5, 2026

概括

No abstract available in PubMed .

关键词:

一个IL-18 美国检查点抑制剂细胞因子免疫细胞因子

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相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.