比较的转录学揭示了成年双边肠道的共同前后后分子蓝图
Stefano Davide Vianello1, Ching-Yi Lin2, Wahyu Cristine Pinem2,3
1Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Yilan, Taiwan.
PLoS biology
|January 6, 2026
概括
研究人员确定了保留的转录因子模块,这些模块是成年双边肠道的模式. 这些发现揭示了早期肠道发育如何与成年人体解剖有关,为身体计划的演变提供了洞察力.
科学领域:
- 发展生物学 发展生物学
- 进化生物学 进化生物学
- 基因组学就是基因组学.
背景情况:
- 通过肠道是双边生物的关键特征,在早期发育中保留了分子机制.
- 然而,成年人肠道组织和前后 (AP) 轴专业化在变形后的双边血统之间有很大差异.
- 胚胎肠道模式与成年肠道分子组织之间的关系仍然不太清楚.
研究的目的:
- 为了研究成年人肠道的分子细分在不同的双边.
- 为了识别管理成年人肠道模式沿AP轴的保存和谱系特定的转录程序.
主要方法:
- 对成年人肠道进行了转录组分析,这些肠道来自五种遗传学信息丰富的物种:鱼,海刺,半带动物,头带动物和脊椎动物.
- 使用公正的分析来识别保存转录因子 (TF) 模块.
主要成果:
- 确定了双部分转录程序,定义了成人肠道中的AP功能细分.
- 涉及Hox,ParaHox和其他TFs的模式系统,以前从幼虫发育中已知,在成年组织中保持着.
- 确定了五个对应于AP肠道区的保存TF模块,显示了跨物种的阐述或转移.
结论:
- 沿着双边肠道推断了保存和修改的成年AP模式模块.
- 这些发现使得祖先双边特征的重建成为可能.
- 这项研究对理解双边身体规划的演变有深远的影响.
相关概念视频
Gastrulation
66.1K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
66.1K
Anatomy of the Gastrointestinal System
2.6K
The human digestive system is an intricate and essential network for nutrient absorption and waste elimination. It encompasses the gastrointestinal (GI) tract and several accessory organs.
Here's a detailed walkthrough of this complex system:
Here's a detailed walkthrough of this complex system:
2.6K
Comparative Excretory Systems
26.4K
Animals have evolved different strategies for excretion, the removal of waste from the body. Most waste must be dissolved in water to be excreted, so an animal’s excretory strategy directly affects its water balance.
26.4K
Anatomy of the Intestines
86.7K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.7K


