乳腺癌妇女持续化疗诱导脱发的种族和民族差异
Danbee Kang1,2, Lukas Kraehenbuehl3,4,5, Haseen Lee1,2
1Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Republic of Korea.
JAMA network open
|January 6, 2026
概括
长期化疗诱导的脱发症 (PCIA) 影响亚洲女性不成比例,导致严重的痛苦. 这项研究强调了PCIA发病率和心理影响的种族差异,强调了需要量身定制的支持.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 心理社会瘤学
背景情况:
- 化学疗法引起的持续性脱发 (PCIA) 是癌症治疗的一个令人痛苦的副作用.
- 目前关于PCIA发病率和相关痛苦的种族和民族差异的数据有限.
- 了解这些差异对于公平的患者护理和支持至关重要.
研究的目的:
- 调查患有乳腺癌的女性中PCIA发病率的种族和民族差异.
- 评估跨种族和种族群体与脱发相关的心理痛苦的差异.
- 从基线到化疗后12个月追踪这些结果.
主要方法:
- 一项前性跨国队列研究,涉及接受化疗的乳腺癌妇女.
- 进行了三眼镜评估和验证的痛苦问卷 (化疗诱导的脱发困扰量表 - CADS).
- 在基线和化疗后12个月收集的数据,分析于2025年进行.
主要成果:
- 亚洲女性的PCIA发病率最高 (42.1%),其次是白人 (22.2%),黑人 (10.0%) 和西班牙裔/拉丁裔 (5.1%).
- 亚洲妇女在基线时表现出最厚的毛轴,但毛囊密度最低.
- 与白人女性相比,亚洲女性报告了CADS得分的最大增加,特别是在情感和活动相关的领域.
结论:
- 在PCIA的发病率和心理影响方面存在显著的种族和民族差异.
- 亚洲女性承受PCIA和相关痛苦的最大负担.
- 这些发现需要个性化咨询,对文化敏感的心理社会支持,以及在治疗化疗相关的脱发症时考虑药物遗传因素.
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