性别确认激素治疗和血管健康:走在谨慎与自信之间的界限上
Virginie Grouthier1,2, Marion Camoin1, Sami Fawaz3
1Department of Endocrinology, Diabetes and Nutrition, Centre Hospitalier Universitaire de Bordeaux, Haut-Leveque Hospital, F-33604 Pessac, France.
European journal of preventive cardiology
|January 6, 2026
概括
性别确认激素治疗可能会加速跨性别女性的动脉样硬化,特别可通过冠状动脉计算机断层扫描血管学检测. 需要进一步的研究来指导跨性别者的心血管风险管理.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
背景情况:
- 对于跨性别者的心血管 (CV) 风险评估尚未得到充分理解.
- 性别确认激素治疗 (GAHT) 可能会增加心血管风险.
- 传统的CV风险工具可能低估了年轻跨性别人口的风险.
研究的目的:
- 评估经过GAHT的跨性别个体的早期CV风险修改.
- 评估创新的成像技术,以评估心血管风险.
主要方法:
- 在波尔多大学医院进行前性单中心研究.
- 包括跨性别男性 (TM) 和跨性别女性 (TW) 开始或继续GAHT.
- 在基线和18个月使用了临床,生物和心血管成像 (冠状动脉度评分,冠状动脉计算机断层扫描血管造影,3维上大动脉干超声波)
主要成果:
- 包括34名参与者 (17个TM,17个TW).
- 变性女性呈现出更大动脉样硬化发展的趋势,心动脉斑块体积增加和冠状动脉斑块进展 (在TM中70%vs22%).
- 冠状动脉计算机断层扫描检测到变性女性的动脉样硬化进展更加明显.
结论:
- 性别确认激素治疗可能会导致变性女性更明显的动脉样硬化进展.
- 先进的成像,如冠状动脉计算机断层扫描血管造影,可能对跨性别个体的CV风险评估有价值.
- 需要进行更大规模的长期研究,以指导跨性别人群中心血管健康的预防策略.
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