通过拉索-考克斯回归综合方法揭示的晚期杆菌病的预后决定因素和死亡风险
Zhong Hong1, Yinlong Li2,3,4,5,6, Shiqing Zhang7
1School of Finance, Taxation and Public Administration, Tongling University, Tongling, China.
PLoS neglected tropical diseases
|January 6, 2026
概括
这项研究确定了使用LASSO-Cox回归的晚期istosomiasis患者的关键生存风险因素. 一个开发出来的名录图 (nomogram) 帮助临床医生预测死亡风险和个性化患者治疗策略.
科学领域:
- 医学研究 医学研究
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 晚期杆菌体病带来了显著的死亡风险.
- 有效的风险分层对于管理先进的杆菌病患者至关重要.
研究的目的:
- 为了识别先进的istosomiasis 的生存相关的危险因素.
- 开发和验证死亡风险的预测名录.
- 帮助临床医生定制治疗和后续策略.
主要方法:
- 对628名晚期杆菌病患者的回顾性分析.
- 使用LASSO回归用于变量选择和Cox比例危险 (CPH) 建模.
- 使用C指数,AUC,校准曲线和决策曲线分析验证了模型.
主要成果:
- 确定了碳水化合物抗原125,氨酸和II/III等级的炎作为独立的预测因素.
- 拉索-科克斯模型表现出高的区分能力 (C指数0.886培训,0.922验证).
- 诺米图有效地可视化了临床应用的风险预测.
结论:
- 诺米图是识别晚期istosomiasis的高死亡风险患者的实用工具.
- 能够实现个性化的随访和治疗,可能改善长期结果.
- 为需要最密集护理的患者提供有针对性的干预措施.
相关概念视频
Cancer Survival Analysis
645
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
645
Comparing the Survival Analysis of Two or More Groups
548
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
548
Assumptions of Survival Analysis
391
Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
391
Kaplan-Meier Approach
556
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
556
Introduction To Survival Analysis
738
Survival analysis is a statistical method used to study time-to-event data, where the "event" might represent outcomes like death, disease relapse, system failure, or recovery. A unique feature of survival data is censoring, which occurs when the event of interest has not been observed for some individuals during the study period. This requires specialized techniques to handle incomplete data effectively.
The primary goal of survival analysis is to estimate survival time—the time...
The primary goal of survival analysis is to estimate survival time—the time...
738
The Mantel-Cox Log-Rank Test
990
The Mantel-Cox log-rank test is a widely used statistical method for comparing the survival distributions of two groups. It tests whether a statistically significant difference exists in survival times between the groups without assuming a specific distribution for the survival data, making it a non-parametric test. This flexibility makes the log-rank test particularly valuable in medical research and other fields where the timing of an event, such as death or disease recurrence, is of...
990


