医院出院后潜在处方级联的发生:一个队列研究
Atiya K Mohammad1,2, Johanna H M Driessen3,4, Jacqueline G Hugtenburg5
1Department of Clinical Pharmacy, OLVG Hospital, Amsterdam, the Netherlands.
Pharmacoepidemiology and drug safety
|January 6, 2026
概括
出院后的处方级联 (PC) 是常见的,药物引起药物不良反应 (ADRs),导致新的处方. 这些级联往往涉及外部医疗保健提供者,突出了协调差距.
科学领域:
- 药物监督 药物监督 药物监督
- 药品安全 药品安全
- 改善医疗保健质量 改善医疗保健质量
背景情况:
- 处方级联 (PCs) 发生在药物的不良药物反应 (ADR) 导致新处方时.
- 在住院期间开始服用药物可能会导致出院后的不良反应和PC,特别是在分散的护理中.
- 了解出院后的PC对于患者安全和药物管理至关重要.
研究的目的:
- 评估医院出院后潜在的处方级联的累积发病率.
- 为了确定参与为这些级联处方标记药物的医疗保健提供者.
- 评估供应商间沟通对药物安全性的影响.
主要方法:
- 一项队列研究分析了在2019-2023年期间与预选PC (n=20) 相关的特定指数药物开始服用的成年患者.
- 使用医院和国家药物记录确定了潜在的PC,将PC定义为治疗索引诱导ADR的标记药物.
- 对于PC具有≥10指数药物发起者的累积发病率计算;对PC具有≥10标志物药物发起者的外部处方率进行评估.
主要成果:
- 在24282名开始使用索引药物的患者中,确定了502名潜在的PC.
- 17个PC的累计发病率在0%至12.3%之间.
- 对于有足够数据的12个PC来说,31.8%至92.8%的标记药物是由医院以外的提供者处方的.
结论:
- 释放后潜在的处方级联发生,累计发生率显著.
- 标记剂药物经常被医疗保健提供者在发起医院以外处方.
- 需要改善护理协调,以减轻与出院后处方级联相关的风险.
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