Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Relationship among Sleep Disturbance, Stress, and Suicidal Ideation in Clinical High Risk for Psychosis.

Schizophrenia bulletin open·2026
Same author

Computerized assessments of emotional expression and emotional reactivity predict negative symptoms in individuals at clinical high-risk for psychosis.

Psychological medicine·2026
Same author

Value representation in youth psychopathology: evidence of a transdiagnostic risk mechanism for psychosis.

Translational psychiatry·2026
Same author

Impaired Hippocampal Circuitry and Memory Dysfunction in Schizophrenia.

Nature. Mental health·2026
Same author

Premorbid adjustment problems, negative symptoms, and cognitive impairment in a large international sample at clinical high risk for psychosis: Findings from the Accelerating Medicines Partnership-Schizophrenia.

Schizophrenia bulletin·2026
Same author

Echoes of trauma: The impact of hippocampal impairments on reward and motivational dysfunction in psychosis.

Neuroscience and biobehavioral reviews·2026

相关实验视频

Updated: Jan 13, 2026

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
08:07

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Published on: August 24, 2016

9.6K

此前的新奇性激发了未来的中游膜点检测目标.

Blake L Elliott1,2, Kathleen J O'Brien1, Matthew Fain3

  • 1Department of Psychology and Neuroscience, Temple University, Philadelphia, PA 19122.

Proceedings of the National Academy of Sciences of the United States of America
|January 6, 2026
PubMed
概括

检测新奇事物涉及海马,它为以前额叶皮质 (PFC) 影响的目标导向行为启动多巴胺基中脑 (VTA). 这一连续的大脑过程优化了对环境变化的适应性反应.

关键词:
目标导向的行为是目标导向的行为.在海马体内,海马体新鲜感 新奇性 新奇性前额叶皮层前额叶皮层腹部的顶部区域.

更多相关视频

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles
09:27

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles

Published on: August 25, 2020

4.7K
Pavlovian Conditioned Approach Training in Rats
06:57

Pavlovian Conditioned Approach Training in Rats

Published on: February 4, 2016

11.4K

相关实验视频

Last Updated: Jan 13, 2026

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
08:07

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Published on: August 24, 2016

9.6K
An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles
09:27

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles

Published on: August 25, 2020

4.7K
Pavlovian Conditioned Approach Training in Rats
06:57

Pavlovian Conditioned Approach Training in Rats

Published on: February 4, 2016

11.4K

科学领域:

  • 神经科学是一个神经科学.
  • 认知科学 认知科学
  • 计算神经科学是一种神经科学.

背景情况:

  • 适应性行为需要检测和响应环境变化.
  • 新性检测对于标志这些变化和准备目标相关信息至关重要.
  • 作为一个连续的过程,新奇性检测 (海马) 和目标导向行为 (VTA,PFC) 的神经支尚未得到充分理解.

研究的目的:

  • 研究海马,VTA和PFC之间在新奇发现和目标参与期间的时间相互作用.
  • 阐明依次的神经过程是适应环境变化的基础.

主要方法:

  • 使用具有前预测能力的功能性MRI (fMRI) 模型.
  • 检查了人类执行目标检测任务的神经活动,其中包含了新奇性.
  • 分析了海马,VTA和PFC激活模式之间的相互作用.

主要成果:

  • 海马的新奇性检测活动预测了随后的VTA激活,提高了对目标相关目标的准备.
  • 前额叶皮层 (PFC) 的目标导向激活调节了VTA活动,专注于重要的线索.
  • 观察到这些电路的协同和独立功能,影响随后的海马活动.

结论:

  • 分布的神经回路,包括海马,VTA和PFC,连续协调以优化适应性行为.
  • 这项研究揭示了一种时间级联,新奇的检测质量和目标导向区域完善响应.
  • 研究结果提供了关于支持在动态环境中灵活适应的神经机制的见解.