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相关概念视频

Evolution of New Traits in Microbes01:24

Evolution of New Traits in Microbes

Microorganisms evolve rapidly due to their large population sizes and short generation times, often exhibiting measurable changes within days under laboratory conditions. Natural selection acts on standing genetic variation, enabling the retention and amplification of beneficial traits that confer fitness advantages in changing environments.Adaptive Pigment Regulation in RhodobacterIn Rhodobacter, a genus of purple non-sulfur bacteria, light-harvesting pigments such as bacteriochlorophyll and...
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The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

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A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
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灵长类肠道微生物群诱导了小鼠神经发育中的进化突出变化.

Alex R DeCasien1,2,3,4, Jacob E Aronoff5,6, Elizabeth K Mallott6,7

  • 1Computational and Evolutionary Neurogenomics Unit, National Institute on Aging, Bethesda, MD 20892.

Proceedings of the National Academy of Sciences of the United States of America
|January 6, 2026
PubMed
概括
此摘要是机器生成的。

肠道微生物群可能支持灵长类大脑的进化. 不同的灵长类肠道微生物影响了小鼠大脑基因表达,特别是影响大脑物种的能量代谢和潜在的神经发育途径.

关键词:
大脑的进化,大脑的演变.我们的肠道微生物群.它们是灵长类的灵长类.

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科学领域:

  • 进化生物学是进化的生物学.
  • 神经科学是一个神经科学.
  • 微生物学 微生物学

背景情况:

  • 灵长类动物的大脑相对于身体大小非常大,与增加大脑能量供应的代谢适应共同演变.
  • 肠道微生物群 (GM) 影响宿主新陈代谢,但其在灵长类动物大脑进化中的作用尚不清楚.

研究的目的:

  • 研究肠道微生物组合在灵长类大脑进化中的潜在作用.
  • 确定灵长类肠道微生物是否影响宿主大脑基因表达和新陈代谢.

主要方法:

  • 没有细菌的小鼠被接种了来自人类 (大脑), (小脑) 和松鼠 (大脑) 的肠道微生物群.
  • 在接种疫苗的小鼠中分析了大脑基因表达和代谢途径.

主要成果:

  • 小鼠大脑基因表达的差异反映了基于转基因起源的实际灵长类大脑之间的差异.
  • 来自大脑灵长类动物 (人类和松鼠) 的肠道微生物群调高了与能源生产相关的基因.
  • 人类转基因特别增强了氧化酸化基因表达和葡萄糖代谢途径,同时降低了与神经发育障碍相关的基因.

结论:

  • 特定物种的肠道微生物组成可以影响宿主大脑的新陈代谢.
  • 肠道微生物群可能在灵长类大脑进化 (脑化) 中发挥了支持作用.
  • 由于这些发现的初步性质,需要进一步研究.