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降低血DHEAS和BDNF水平作为认知能力下降的指标

Marcela Konjevod¹, Nikola Balic¹, Lucija Tudor¹

¹Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Ruder Boskovic Institute, Zagreb, Croatia.

Progress in neuro-psychopharmacology & biological psychiatry

|January 6, 2026

概括

较低水平的脑衍生性神经营养因子 (BDNF) 和脱乙硫酸 (DHEAS) 与中度至严重的认知障碍有关. 这些因素可以作为认知衰退的生物标志物.

科学领域:

神经科学是一个神经科学.
生物化学生物化学
老年学是指老年学的学科.

背景情况:

认知能力下降是衰老的一个常见方面,可能导致轻度认知障碍和痴呆症.
神经营养素如脑衍生神经营养因子 (BDNF) 和神经类固醇如脱氨 (DHEA) 和其硫酸盐 (DHEAS) 对于认知功能至关重要,并且在神经认知障碍中经常发生变化.

研究的目的:

研究BDNF和SULT2A1 (一种参与DHEA转化为DHEAS的酶) 的基因变异.
评估个人BDNF和DHEAS的血水平,包括从正常认知到严重障碍的认知功能.

主要方法:

在453名参与者中使用迷你心理状态检查 (MMSE) 和时钟绘图测试 (CDT) 评估认知功能.
进行了BDNF (rs6265) 和SULT2A1 (rs2637125) 多态的基因定型.
通过酶相关免疫吸收试验 (ELISA) 测量了血BDNF和DHEAS度.

主要成果:

与正常认知水平相比,患有中度至严重认知障碍的参与者表现出明显较低的血BDNF和DHEAS水平.
观察到男性比女性BDNF水平更明显的变化.
研究的基因多态 (BDNF rs6265,SULT2A1 rs2637125) 与认知衰退或BDNF/DHEAS的血水平之间没有发现显著的关联.

结论:

血BDNF和DHEAS水平在中度至重度认知障碍的人群中显著降低.
迷你心理状态检查 (MMSE) 在根据这些生物标志物区分认知障碍水平方面表现出比时钟绘图测试 (CDT) 更大的有效性.
作为认知衰退的外围生物标志物,BDNF和DHEAS显示出潜在的潜力,这需要进一步调查它们在神经认知障碍中的治疗潜力.

关键词:

这就是为什么BDNF是BDNF.认知功能认知功能他们是DHEASAS.基因多态化是基因的多态化.没有 rs2637125 的钱.需要 rs6265 的钱.

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