昆虫感染菌的胆汁提取物对引起炎的病原体Streptococcus pyogenes具有快速杀菌和抗病毒作用
Tananya Tanabat1, Sakkarin Lethongkam1, Supayang Piyawan Voravuthikunchai1
1Division of Biological Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand; Center of Antimicrobial Biomaterial Innovation-Southeast Asia, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Journal of ethnopharmacology
|January 6, 2026
概括
杆菌感染性胆汁提取物显示出对Streptococcus pyogenes的强有力的抗菌和抗病毒作用,为抗生素耐药性感染提供了天然替代品.
科学领域:
- 植物化学 植物化学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 斯氏菌 (Streptococcus pyogenes) 引起喉炎,抗生素耐药性的增加带来了临床挑战.
- 传统上,Quercus infectoria的胆汁在亚洲医学中用于治疗喉疾病.
研究的目的:
- 为了研究Quercus infectoria胆汁提取物对Streptococcus pyogenes的抗菌和抗病毒性质.
主要方法:
- 使用LC-MS的植物化学分析.
- 抗菌检测 (MIC,MBC,时间杀).
- 抗病毒性测试 (血液溶解,生物膜抑制,SEM,TEM,定数感应,基因表达分析).
主要成果:
- 提取物中含有丰富的素,酸和黄酸.
- 它对S. pyogenes表现出显著的抗菌活性,包括临床分离物.
- 提取物抑制了血液溶解,生物膜形成,定数感应,并降低了病毒性基因的调节.
结论:
- 昆感染菌胆汁提取物有效地抑制了S. pyogenes的生长和毒性.
- 这支持其作为天然治疗剂对抗耐药性链球菌感染的潜力.
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