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[细胞蛋白表达及其与结直肠癌病理特征的相关性]

L He¹, Y Wang², P K Song²

¹Department of Pathology, Beijing Hospital/National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.

Zhonghua bing li xue za zhi = Chinese journal of pathology

|January 6, 2026

概括

细胞蛋白 (PrPc) 表达与晚期结直肠癌阶段,转移和不良预后相关. 淘汰PrPc会抑制结肠直肠癌干细胞的生长,入侵和迁移,这表明PrPc可以促进瘤的进展.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
病理学病理学病理学

背景情况:

结肠直肠癌 (CRC) 是一个重要的全球健康问题.
了解与CRC转移和预后相关的分子标志物对于改善患者的治疗结果至关重要.

研究的目的:

为了研究细胞蛋白 (PrPc) 和CD44在结直肠癌中的表达.
分析PrPc和CD44表达与结直肠癌转移和预后之间的相关性.
阐明PrPc在结直肠癌干细胞扩散,入侵和迁移中的作用.

主要方法:

对212个结直肠癌样本进行了回顾性分析.
对于PrPc和CD44表达的免疫组织化学和免疫光染色.
在结直肠癌干细胞 (P6C) 中进行PrPc淘汰,以评估功能影响.
西方斑点,痕和Transwell测试用于评估细胞生长,迁移和入侵.

主要成果:

在晚期瘤 (T4),差异化瘤以及淋巴结或远程转移的瘤中观察到 PrPc 表达升高.
PrPc和CD44的同时表达与瘤分化,T阶段和转移有显著的相关性 (P<0.05).
PrPc淘汰赛抑制了转移相关的蛋白质 (N-cadherin,Twist) 并抑制了癌症干细胞的增殖,入侵和迁移 (P<0.01).

结论:

PrPc表达与结直肠癌的发生和进展有关.
PrPc作为瘤入侵,转移和结直肠癌的预后的潜在指标.
通过影响癌症干细胞行为,PrPc促进结直肠癌的侵袭和转移.

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