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产前DINP暴露产生的肝肥胖症和潜在机制的影响
Yahui Jin1, Junli Zhao1, Xinjing Wang1
1Department of Children and Adolescences Health, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China.
Toxicology and applied pharmacology
|January 6, 2026
概括
产前暴露于迪松尼尔甲酸盐 (DINP) 会在后代中引起性别特异性肝损伤. 雄性表现出更严重的脂质积累,而雌性表现出保护性代谢适应,突出显示肠肝轴的破坏.
科学领域:
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
- 毒理学 毒理学 毒理学
背景情况:
- 产前暴露于二松尼尔甲酸盐 (DINP) 对后代的肝脂代谢有性别特异的影响.
- 这些影响背后的机制,特别是涉及肠肝轴的机制,尚未完全理解.
研究的目的:
- 研究产前DINP暴露对后代肝脂代谢的性别特异性影响.
- 探索肠肝轴在调解这些效应中的参与.
主要方法:
- 怀孕的小鼠接受了DINP;后代接受了生长,组织病理学,脂质分析,基因表达和便代谢学分析.
- 研究脂肪酸氧化,脂质调节通路 (PPARα,PPARγ) 和肠道微生物代谢物的改变.
主要成果:
- 男子后代表现出生长迟缓,肝硬化,高甘油三/胆固醇,脂肪酸氧化受损,以及肠道代谢物 (α-烯酸,乌比奎) 变化.
- 雌性后代表现出较温和的脂质沉积,维持脂肪酸β氧化 (CPT-1A),以及改变的糖脂代谢,表明补偿性适应.
- 暴露于DINP会以取决于性别的方式破坏肠肝轴.
结论:
- 产前DINP暴露会通过肠肝轴的破坏诱导性别特异性肝硬化症.
- 由于脂肪酸氧化受损,男性更容易受到脂质积累的影响.
- 雌性表现出补偿机制,缓解肥胖症,表明不同的易感性.
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