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作为乳腺癌的预后生物标志物的雄激素受体:系统性审查和元分析

Manjusha Pal¹, Ankita Chakrawal¹, Bhavana Singh¹

¹HTAIn Resource Centre, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.

Critical reviews in oncology/hematology

|January 6, 2026

概括

雄激素受体 (AR) 表达显示了乳腺癌 (BC) 存活的积极趋势. 然而,它的预后价值仅在雌激素受体 (ER) 阳性BC中具有意义,因此需要进一步调查.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

乳腺癌 (BC) 是全球女性癌症死亡的主要原因.
雄激素受体 (AR) 在BC预后中的作用尚不清楚.
抗癌症可以同时具有支持和反瘤的作用.

研究的目的:

在BC患者中评估AR表达和生存结果 (DFS,OS) 之间的关联.
为了研究不同BC亚型的AR的预后价值.
确定AR状态是否可以为个性化BC治疗策略提供信息.

主要方法:

按照PRISMA指南进行系统审查和元分析.
在多个数据库中进行了搜索 (PubMed,Scopus,科学网,Embase,Cochrane图书馆).
包括24项研究 (17,329名患者) 基于AR状态和其他生物标志物的生存数据.
使用随机效应模型将危险比率 (HR) 和95%置信区间 (CI) 结合起来.

主要成果:

抗逆转录病毒阳性显示了改善OS (HR=0.59) 和DFS (HR=0.62) 的非显著趋势.
在AR和ER阳性BC亚组中观察到显著的生存益处 (OS和DFS).
由于异质性,其他BC子集 (例如TNBC,HER2阳性BC) 的结果含糊不清.

结论:

AR表达与ER阳性乳腺癌的更好的预后有关.
在TNBC和HER2阳性BC中AR的预后意义需要进一步澄清.
标准化AR评估和前性研究对于验证其在个性化BC治疗中的作用至关重要.

关键词:

雄激素受体的受体雄激素受体乳腺癌乳腺癌乳腺癌没有疾病的生存率.进行元分析.预后预后预后幸存率幸存率生存率

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