协生菌对抗多药耐药细菌的抗菌和抗菌膜作用:Acinetobacter baumannii和Enterococcus faecalis
Niki Laal-Kargar1, Samaneh Dolatabadi2, Mahnaz Mohtashami1
1Department of Microbiology, Ne.C., Islamic Azad University, Neyshabur, Iran.
概括
益生菌和协生菌在对抗抗生素耐药性细菌,如Acinetobacter baumannii和Enterococcus faecalis等方面表现有前途. 这些有益的微生物,特别是与益生菌结合时,有效地抑制了细菌的生长,减少了生物膜的形成,提供了作为天然生物控制剂的潜力.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 抗生素耐药性对全球健康构成重大挑战,需要开发新的抗菌和抗菌膜策略.
- 多抗药性 (MDR) Acinetobacter baumannii和Enterococcus faecalis是形成生物膜的关键病原体,增加了它们对抗生素的耐药性.
- 益生菌和共生菌正在被探索作为预防和控制感染的潜在替代品.
研究的目的:
- 研究益生菌和共生菌对MDR A. baumannii和E. faecalis的抗菌和抗菌膜特性.
- 评估特定益生菌在增强益生菌抗菌活性方面的疗效.
主要方法:
- 来自四个Lactobacillus菌株的无细胞超级生物与A. baumannii和E. faecalis的20个临床MDR分离物进行了测试.
- 使用井扩散和微稀释方法评估了抗微生物和抗菌膜活性.
- 评估了益生菌对益生菌活性的影响 (酸盐,拉芬,酸盐,三糖,胰岛素, рибофлавин).
主要成果:
- 与酸盐和三糖相结合的Lactobacillus rhamnosus显示出对MDR A. baumannii和MDR E. faecalis.有显著的抗菌活性.
- 益生菌增强了益生菌的抑制作用,特别是在与阳性E. faecalis.相比,针对阴性A. baumannii.
- 益生菌和共生菌有效地减少了两种病原体的生物膜形成,特定的组合显示出高抑制率.
结论:
- 协生菌表现出显著的抗菌膜活性,支持它们在对抗耐药细菌感染方面的潜在用途.
- 益生菌和共生菌可以作为有效的生物控制剂和辅助剂在治疗策略对抗MDR病原体.
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