芯片上的瘤与分子病理学的联盟,对抗转移性疾病
1Department of Medicine and Sciences of Aging, "G. d'Annunzio" University" of Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy. edicarlo@unich.it.
Journal of biomedical science
|January 6, 2026
概括
定制生物打印瘤为研究转移和耐药性提供了现实的模型. 将这些与omics数据和AI集成,可以个性化癌症治疗并改善患者的治疗结果.
科学领域:
- 生物技术是生物技术.
- 在瘤学瘤学.
- 医疗工程 医学工程
背景情况:
- 转移是癌症死亡的主要原因,在治疗中构成重大挑战.
- 克服治疗耐药性对于改善转移性癌症患者的长期生存率至关重要.
- 了解瘤进展机制和识别耐药基因对于开发有效的治疗策略至关重要.
研究的目的:
- 审查在器官芯片平台上的定制生物打印瘤的应用,以研究转移.
- 探索分子病理学和OMICS数据与患者特定模型的整合.
- 讨论人工智能 (AI) 在管理针对个性化癌症治疗的复杂数据集中的作用.
主要方法:
- 使用定制生物打印瘤,模仿瘤周围组织相互作用.
- 将生物打印模型集成到芯片器官平台中,以实现现实的微环境模拟.
- 利用分子病理学和多omics数据与AI一起进行数据分析.
主要成果:
- 生物打印瘤为研究转移提供了高度现实的,针对患者的模型.
- 这些模型有助于识别治疗点和耐药性机制.
- 这种方法可以设计定制的药物管理协议,以对抗转移和耐药性.
结论:
- 来自患者的生物打印瘤和器官可以用于临床目的,从而能够动态评估癌症治疗反应.
- 标准化的4D和5D生物打印协议,结合先进的诊断和人工智能,可以加速生物标志物识别和治疗调整.
- 这种综合的多学科方法有望通过量身定制的治疗方案来加强转移性疾病的临床管理.
相关概念视频
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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