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内不分化的多形肉瘤的管理:系统性审查

Noah B Drewes¹, Jeffrey Z Nie², Rafal Chojak³

¹Department of Surgery, Division of Neurosurgery, Southern Illinois University School of Medicine, Springfield, IL, USA. ndrewes45@siumed.edu.

Neurosurgical review

|January 6, 2026

概括

大脑的未分化形肉瘤 (UPS) 是罕见的和积极的. 外轴瘤显示出更好的生存率,化学辐射的手术切除为这些具有挑战性的内瘤提供了最好的结果.

科学领域:

神经瘤学神经瘤学
手术病理学手术病理学
软组织瘤软组织瘤

背景情况:

不分化形肉瘤 (UPS) 是一种罕见的,具有侵略性的软组织瘤,其起源不明.
内UPS非常罕见,经常被误诊,缺乏确定的治疗指南.
临界神经解剖学可以限制内UPS的完整手术切除.

研究的目的:

系统地审查和整合关于内UPS的现有文献.
评估内UPS的预后因素和管理策略.
确定最佳的治疗方法,以改善患者的治疗结果.

主要方法:

按照PRISMA指南进行了系统审查.
在PubMed和Embase搜索了内UPS和相关术语.
包括组织学证实病例和报告结果的研究;分析了生存数据.

主要成果:

分析了40项研究中的48名患者;中位数年龄为45岁.
大多数瘤是额外轴的 (45%); 82.1%的瘤实现了总体切除.
平均无事件生存时间为18个月,总生存时间为24个月.

结论:

内UPS具有侵略性,预后比外UPS差.
外轴瘤位置是一个显著的积极预后因素.
手术切除与辅助化学辐射相结合,证明了最长的中位生存期.

关键词:

大脑瘤大脑瘤恶性纤维细胞瘤恶性纤维细胞瘤神经外科神经外科预后预后预测预测系统性审查系统性审查不分化的多形形肉瘤.

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