怀孕期间母亲暴露于和出生体重之间的关联:系统性审查和元分析
Shuxia Zhang1, Lili Li1, Yanfei Zuo2
1Department of obstetrics, Dezhou Women and Children's Hospital, Dezhou, 253000, China.
BMC pediatrics
|January 6, 2026
概括
产前暴露可能会对出生体重产生负面影响,特别是在更高度和更晚的怀孕期间. 这一元分析突出了与较低新生儿出生体重相关的特定条件.
科学领域:
- 环境健康 环境健康
- 围产期流行病学 围产期流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 流行病学研究表明,产前暴露与出生体重 (BW) 之间存在潜在的负面关联,但研究结果仍然没有确定性.
- 需要对现有证据进行全面的定量综合,以澄清这种关系.
研究的目的:
- 量化总结关于产前暴露与出生体重 (BW) 之间的关联的证据.
- 调查观察到的效应中异质性的潜在来源.
主要方法:
- 在PubMed和Scopus数据库中进行了系统的文献搜索,直到2024年3月.
- 使用随机效应模型将标准化回归系数 (β) 和95%置信区间 (CI) 结合起来.
- 根据样本类型,样本大小,评估方法,度和采样三月份进行了分层分析.
主要成果:
- 对41项研究 (128487名参与者) 的分析显示,产前暴露与BW (β = -0.002,P = 0.06) 之间没有显著的总体关联.
- 然而,分层分析表明,在涉及胎盘暴露 (β = -0.144,P = 0.02),分娩暴露 (β = -0.010,P = 0.01) 和第三季度暴露 (β = -0.0003,P = 0.004) 的研究中,暴露和新生儿BW之间存在逆关系.
- 对于较高的血液水平 (≥2.09μg/L) 和胎盘水平 (≥10μg/kg) 观察到与BW显著的负相关性.
结论:
- 产前暴露可能与出生体重有负面关联,特别是在血液和胎盘中度较高时.
- 怀孕后期 (第三季度和分娩时) 的暴露和胎盘的暴露与较低的新生儿出生体重有显著的联系.
- 这些发现强调了在怀孕期间监测水平的重要性,特别是在晚期.
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