体微生物接表明协作机制增强酸供应,以减轻羊羔的断奶压力
Tianrong Chen1,2, Shaobo Yu1,2, Kui Li1,2
1Institute of Dairy Science, College of Animal Sciences, Zhejiang University, 866 Yuhangtang Rd, Hangzhou, 310058, P. R. China.
Microbiome
|January 6, 2026
概括
通过口服注射成年肠微生物群,可以帮助幼羊通过促进 propionate 生产和能量代谢来克服断奶压力. 这种微生物转移增强了肠道健康,并有助于反动物的饮食过渡.
科学领域:
- 流体微生物学 流体微生物学
- 动物营养动物营养
- 代谢生理学 代谢生理学
背景情况:
- 断奶对年轻的反动物造成代谢压力,这是由于能量不足造成的.
- 乳头微生物种植可能减轻断奶压力,但机制尚不清楚.
研究的目的:
- 为了研究口服注射成年肠微生物群对胡羊羔断奶压力的影响.
- 阐明微生物移植影响能量恒温和小麦芽发酵的机制.
主要方法:
- 48只胡羊羔被分为接种疫苗 (类微生物群) 和对照组.
- 评估了乳头发酵,血液代谢物,肝脏糖原,葡萄糖原基因表达和乳头微生物组的变化.
- 利用基因组解析的元基因组学和体外共同培养实验.
主要成果:
- 注射增加了 propionate,提高了肝脏葡萄糖原基因 (pyruvate carboxylase,葡萄糖-6-酸酶) 的调节,并增强了肝脏葡萄糖的产生.
- 微生物组分析显示乳酸盐生产者 (Olsenella,Sharpea) 和酸盐生产者 (Megasphaera elsdenii,Prevotellaceae,Succinivibrionaceae,Erysipelotrichaceae) 的增加.
- 确定了特定微生物 (例如,Megasphaera elsdenii,Bilifractor porci) 之间的协同作用,用于酸盐生产.
结论:
- 口服注射建立了微生物联盟,增强了乳酸盐和酸盐的生产,改善了肝脏的葡萄糖生成和能量稳定.
- 这种微生物调节减轻了断奶压力,并促进了年轻反动物的代谢弹性.
- 体微生物种植是一种有前途的策略,可以促进牲畜的饮食过渡.
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