乳酸:阐明其在人类健康中不可或缺的作用
Shengxin Zhang1, Jie Wang2, Ziyu Xu1
1Department of Radiotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, National Clinical Research Center for Geriatrics, Sichuan University, Chengdu, 610041, China.
Molecular cancer
|January 6, 2026
概括
乳酸是新陈代谢,免疫和表观遗传学的关键调节剂,既作为能量来源,又作为信号分子. 新兴研究强调了它在癌症和代谢障碍中的作用,提供了新的治疗途径.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- 乳酸,曾经仅被视为代谢副产品,现在被认为对细胞能量,免疫反应和表观遗传修饰具有关键作用.
- "乳酸"机制突出了乳酸作为替代能量基质的功能,而它的信号传导能力影响了器官之间的生理和病理过程.
研究的目的:
- 审查乳酸在健康和疾病中的多方面的作用.
- 探索针对乳酸代谢,运输和信号通路的新兴治疗策略,特别是针对癌症和代谢障碍.
主要方法:
- 文献综述综合了关于乳酸的功能目前的研究.
- 对乳酸在乳糖化中的参与进行分析,这是一个翻译后的修改.
- 检查乳酸对瘤微环境的影响,包括免疫抑制和血管生成.
主要成果:
- 乳酸盐通过激素和非激素的乳化显著影响基因表达.
- 乳酸积累与心血管,代谢和神经退行性疾病有关.
- 乳酸在促进瘤生长,免疫抑制和瘤微环境中的血管生成方面发挥着关键作用.
结论:
- 乳酸是重要的信号分子,在正常生理学和疾病发病过程中具有深远的影响.
- 向乳酸代谢为各种疾病,特别是癌症和代谢疾病提供了有前途的治疗机会.
- 进一步的研究和乳酸向疗法的临床转化是有必要的.
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