针对中性粒细胞驱动的免疫抑制:克服免疫检查点抑制剂耐药性的策略
Ying Ning1,2, Ke Lei2, Xinyan Gao1
1Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Clinical and translational medicine
|January 6, 2026
概括
与瘤相关的中性粒细胞 (TAN) 可以通过促进耐药性来阻碍免疫检查点阻塞 (ICB) 治疗. 针对这些中性粒细胞提供了一个有希望的策略,以提高ICB在癌症治疗中的有效性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症治疗 癌症治疗
背景情况:
- 免疫检查点封锁 (ICB) 已经改变了癌症治疗,但面临着低响应率和获得抗性的挑战.
- 与瘤相关的中性粒细胞 (TAN) 在调节瘤免疫微环境方面发挥着至关重要的作用,并与ICB耐药性有关.
研究的目的:
- 系统地审查中性粒细胞在ICB耐药性中的作用.
- 探索涉及TAN和ICI的临床指标,耐药性机制和组合治疗策略.
主要方法:
- 对ICB耐药性中性粒细胞现有知识的系统审查.
- 分析临床指标 (NLR,TAN丰度) 作为ICI反应的预测指标.
- 检查TAN介导的抵抗机制 (T细胞抑制,血管生成,TMB升高).
- 针对TAN (招聘,两极化,NET) 的组合策略的评估.
主要成果:
- 像NLR和TAN丰度这样的中性细胞生物标志物可以预测ICI反应和患者的预后.
- 通过免疫重塑,血管新生促进和增加瘤突变负担,TANs有助于ICB抵抗.
- 通过各种策略准TAN显示出克服阻力的潜力.
结论:
- 将TAN向疗法与ICI整合的组合方法对提高癌症免疫疗法的疗效具有显著的前景.
- 对中性粒细胞介导的抵抗机制和优化组合策略的进一步研究对于推进精确瘤免疫治疗至关重要.
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