在患有白血病的儿童中输血铁过载
Nihal Karadaş1, Erkam Dolapçi1, Ayshe Gadashova1
1Department of Pediatric Hematology, Ege University Faculty of Medicine, Children's Hospital, Izmir, Turkey.
Pediatric blood & cancer
|January 6, 2026
概括
儿童白血病患者经常因为输血而经历铁过载. 使用deferasirox的铁化疗法在治疗这种疾病方面是安全有效的,可以减少铁负担,但副作用轻微.
科学领域:
- 血液学 血液学 血液学
- 儿科瘤学 儿科瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 铁过载是患有白血病的儿科患者的一个重大问题.
- 在白血病患者的慢性输血可以导致过度的铁积累.
- 评估铁状况对于管理与治疗相关的并发症至关重要.
研究的目的:
- 为了检查儿科白血病患者的铁过载.
- 为了评估铁化疗法的安全性和有效性,使用deferasirox.
- 为了确定需要化疗法的预测因素.
主要方法:
- 对208名患有急性白血病的儿童的医疗记录进行了回顾性查.
- 在接受deferasirox和不接受deferasirox的患者之间比较铁状况,包装红细胞 (pRBC) 容量和输血史.
- 确定血清费里的切断值,累积的PRBC体积和PRBC输血数量,以预测化需求.
主要成果:
- 包括193名患者;44人 (22.8%) 接受了铁化疗.
- 需要结合剂的患者的pRBC输血量,累积的pRBC体积和费里水平显著增加.
- 已确立的血清费里的预测截止值 (1952 mcg/L),累积的PRBC体积 (145 mL/kg) 和PRBC输血数量 (12).
- 德费拉西洛克斯在降低铁负担方面表现出有效性和安全性,只有轻度至中度的不良影响.
结论:
- 铁过载是儿童白血病患者的常见并发症.
- 包装红细胞输血的数量和累积输血量与铁过载有关.
- 用deferasirox进行铁化疗法是一种安全有效的策略,用于管理该群体的铁过载.
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