患有内分泌瘤综合征的患者的心理社会结果:系统性审查
Daniël Zwerus1,2,3, Floortje Strobbe1, Annemarie A Verrijn Stuart3
1Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Pediatric blood & cancer
|January 6, 2026
概括
内分泌瘤综合征显著影响患者的生活质量,焦虑和抑郁. 心理社会结果因综合症而异,需要量身定制的研究和护理,特别是对于儿科患者.
科学领域:
- 内分泌学 在内分泌学.
- 心理学 心理学 心理学
- 遗传学 是一个遗传学.
背景情况:
- 内分泌瘤综合征 (ETSs) 由于疾病表现,家族负担和可变透率而存在独特的挑战.
- 对ETS患者心理社会结果的全面理解对于改善护理至关重要.
- 现有的关于心理社会影响的数据需要综合,以确定研究和临床差距.
研究的目的:
- 审查和总结有关ETS患者心理社会结果的现有数据.
- 探索不同ETS中影响心理社会福祉的具体因素.
- 确定未来研究和临床干预的差距和机会.
主要方法:
- 在PubMed,PsychInfo和Embase上进行系统的文献搜索,寻找多发性内分泌瘤 (MEN),·希佩尔-林道 (VHL) 和SDHx基因致病变体 (PVs) 的研究.
- 包括专注于成人和儿科人口心理社会结果的研究.
- 使用CASP和STROBE评估工具进行包含的研究质量评估.
主要成果:
- 确定了36项研究,证据质量各不相同;其中5项包括儿科患者.
- 排放系统严重影响生活质量,焦虑和抑郁;不适应应对和社会经济因素加剧了结果.
- 监测协议的效果不一;在MEN1,MEN2A,MEN2B,VHL和SDHx-PV中,特定的症状和家族史对结果产生了不同的影响.
结论:
- 心理社会结果及其促成因素在各种ETS之间存在显著差异.
- 进一步的研究对于解决被诊断患有ETS的儿童的特定心理社会需求至关重要.
- 需要量身定制的临床方法来管理ETS患者面临的各种心理社会挑战.
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