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在小鼠中由5-MeO-DMT诱导的警觉状态解离

Benjamin J B Bréant^1,2,3, José Prius Mengual^4,5,6, Alexander Andrews^4,5

¹Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. benjamin.breant@icm-institute.org.

Communications biology

|January 6, 2026

概括

像5-MeO-DMT这样的迷幻药在清醒的小鼠中诱导了一种与缓慢的大脑波和瞳孔扩张的解离性大脑状态. 这种状态可以解释迷幻效应,包括幻觉和可塑性.

科学领域:

神经科学是一个神经科学.
心理药理学心理药理学

背景情况:

迷幻药物改变主观经验和行为.
这些变化往往是从心理上看的,而不是作为不同的大脑状态.

研究的目的:

调查5-甲氧-N,N-二甲基三胺 (5-MeO-DMT) 对大脑活动和警的急性影响.
探索由迷幻药物诱导的分离大脑状态的潜力.

主要方法:

从自由移动的成年雄性小鼠中新皮质的慢性电生理记录.
同时进行瞳孔测量以评估警.
使用一种短效迷幻药物5-MeO-DMT.

主要成果:

在清醒,移动的动物中,5-MeO-DMT诱导了与突出皮层缓慢振荡和显著瞳孔扩张的分离状态.
快速眼动 (REM) 睡眠最初被抑制,随后在48小时内过度补偿.
在睡眠剥夺后给予5-MeO-DMT可减少睡眠缓波活动的随后反弹.

结论:

这些发现表明,一种独特的分离状态,结合了清醒和睡眠特征,是迷幻效应的基础.
这种状态可能对幻觉和可塑性重新开放等现象至关重要.

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