非酒精性脂肪肝病与血液水平之间的关联基于NHANES 2017-2020年
Jinlong Chen1, Hanxiang Jiang1, Xinxin Fang2
1Department of Gastroenterology, Guankou Township Center Hospital, Jimei Distinct, Xiamen, Fujian, China.
Clinical and experimental medicine
|January 6, 2026
概括
血水平升高与美国成年人患非酒精性脂肪肝 (NAFLD) 的风险更高有关. 这种关联显示出非线性,积极的剂量反应关系,表明较高的可能会增加NAFLD风险.
科学领域:
- 营养流行病学 营养流行病学
- 毒理学 毒理学 毒理学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的公共卫生问题.
- 微量元素,如在NAFLD病原体中的作用尚未完全理解.
- 了解影响NAFLD风险的环境因素对于预防策略至关重要.
研究的目的:
- 在美国成年人口中调查血度与NAFLD风险之间的关联.
- 探索与NAFLD相关的剂量反应关系和血液的潜在值.
- 检查人口统计学因素 (如性别) 的潜在影响修改.
主要方法:
- 使用国家健康和营养检查调查 (2017-2020) 的数据进行横截面分析.
- 包括3940名符合条件的参与者.
- 用多变量逻辑回归,子组分析,平滑曲线拟合和断片线性回归来评估关系,并通过多次归算检查模型的稳定性.
主要成果:
- 在3940名参与者中,NAFLD患病率为45%.
- 血水平较高的四分位数 (Q3和Q4) 与在完全共变量调整后NAFLD几率比率的增加有显著联系.
- 观察到一个显著的非线性积极的剂量反应关系,每一个1-SD增加的日志转化血对应于NAFLD的1.16调整的几率比. 性别是一个显著的效果修饰因素.
结论:
- 血度升高与美国成年人中NAFLD风险增加显著相关.
- 这种关联遵循非线性,积极的剂量反应模式,表明较高的水平可能会增加NAFLD风险.
- 需要进一步的前性研究来证实这些发现,鉴于NAFLD流行病,这些发现可能会对公共卫生产生重大影响.
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