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用动力学模拟识别昼夜节律相关基因和近视治疗点:使用机器学习算法和门德尔随机化的多组学研究

Jiahao Niu¹, Jia Lin¹, Xianmei Zhou¹

¹Department of Ophthalmology of Affiliated Hospital, Medical School of Ophthalmology & Optometry, North Sichuan Medical College, Nanchong, Sichuan Province, China.

Journal of computer-aided molecular design

|January 6, 2026

概括

这项研究确定了与近视相关的四个关键昼夜节律基因,UTS2显示了因果关系. 8-Bromo-cAMP作为一种潜在的治疗分子出现,证明了与UTS2和BTBD9.9的高结合效率.

科学领域:

眼科和遗传学眼科和遗传学
时间生物学和分子生物学.

背景情况:

近视的患病率在全球范围内不断增加,受遗传和环境因素的影响.
循环节律障碍,特别是黑激素,与折射误差有关,但机制尚未完全理解.

研究的目的:

确定与近视相关的关键昼夜节律相关基因.
为了研究潜在的治疗性小分子,针对这些基因.
探索已识别的基因与近视之间的因果关系.

主要方法:

在GSE136701数据集上的差异基因表达分析.
机器学习模型,GSEA,GO和KEGG路径分析用于基因识别.
药物查,分子对接,孟德尔随机化 (MR) 和单细胞分析.

主要成果:

他们发现了四个关键的昼夜节律基因 (UTS2,BTBD9,S100A3,LGALS9).
8-Bromo-cAMP显示出高结合效率与UTS2和BTBD9,具有稳定的复杂动态.
核磁共振分析证实UTS2和近视之间存在显著的因果关系 (IVW P=0.013).

结论:

预先确定UTS2,BTBD9,S100A3和LGALS9是近视的关键昼夜节律基因.
8-Bromo-cAMP代表了近视治疗的潜在治疗候选者.
UTS2与近视有因果关系,突出了昼夜节律在折射误差发展中的作用.

关键词:

循环节律是循环节律的节奏.机器学习机器学习门德尔的随机化分子对接是分子对接.分子动力学模拟模型近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近视近

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