在局部性膀癌的治疗方面取得了进展
Marie-Pier St-Laurent1, Jussi Nikkola2, Eisuke Tomiyama2
1Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada. mst-laurent@prostatecentre.com.
Nature reviews. Clinical oncology
|January 6, 2026
概括
膀癌管理方面的进展为人们带来了新的希望. 风险分层,生物标志物和疗法方面的创新正在改善非肌肉侵入性膀癌 (NMIBC) 和肌肉侵入性膀癌 (MIBC) 的结果.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 膀癌是一个重大的全球健康挑战.
- 局部化膀癌的范围从非肌肉侵入性 (NMIBC) 到肌肉侵入性 (MIBC).
研究的目的:
- 在过去的十年里,回顾最近在局部膀癌管理方面的进展.
- 突出创新和未来的研究方向塑造临床实践.
主要方法:
- 对NMIBC进行增强型囊镜检查,块切除,以及新的全身/静脉内疗法进行审查.
- 对MIBC进行手术改进,新辅助/辅助疗法 (免疫疗法,抗体-药物合物) 和膀保护策略的分析.
- 探索循环瘤DNA和基于组织的生物标志物,以实现个性化治疗.
主要成果:
- 扩大了NMIBC的治疗选择,特别是Bacillus Calmette-Guérin不反应的疾病.
- 通过术后免疫疗法和新辅助疗法改善MIBC的瘤结局.
- 选择性MIBC患者的膀保护方法在临床上越来越受欢迎.
结论:
- 在局部膀癌管理方面取得了重大进展.
- 生物标志物的进步将推动个性化的治疗和随访.
- 持续的创新有望进一步改善患者护理和治疗结果.
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