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Updated: Jan 13, 2026

Targeted RNA Sequencing Assay to Characterize Gene Expression and Genomic Alterations
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可操作的转录组:用于将RNA测序纳入精密瘤学的框架

Amber Johnson1, Yifei Shen2, Xiaofeng Zheng2

  • 1Molecular Diagnostics Laboratory, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Nature reviews. Clinical oncology
|January 6, 2026
PubMed
概括

综合RNA测序 (RNA-seq) 提供了一种具有成本效益的方法来检测癌症中可操作的生物标志物. 这种方法通过分析RNA水平,基因融合和个性化治疗策略的变异来提高精确瘤学.

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
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