潜在可治愈的结直肠肺转移的管理与同步的全身疗法和皮肤成像导向的热除
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Updated: Jun 17, 2026
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Thermal Ablation for the Treatment of Abdominal Tumors
Published on: March 7, 2011
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Hongjie Fan1,2,3, Bufu Tang4, Xiangjun Dong1,2,3
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Annals of medicine
|January 6, 2026
概括
同步的全身疗法加热废除 (TA) 显著改善了患有寡头转移性结直肠肺转移 (CRLM) 患者的存活率. 与延迟或不进行全身治疗相比,这种方法提供了最好的结果.
科学领域:
- 在瘤学瘤学.
- 肺部医学 肺部医学
- 手术瘤学手术瘤学
背景情况:
- 优化对寡头转移性结直肠肺转移 (CRLM) 的治疗具有挑战性.
- 综合全身疗法和热废除 (TA) 是潜在可治愈的CRLM的关键.
研究的目的:
- 评估同步全身治疗与TA在CRLM患者的生存益处.
- 确定影响TA治疗的CRLM结果的独立预后因素.
主要方法:
- 对326名为CRLM接受TA治疗的患者进行了回顾性队列研究.
- 根据系统治疗时间分组的患者:同步,延迟或没有.
- 用于生存评估的卡普兰-梅尔分析和日志等级测试.
主要成果:
- 同步治疗显示出更高的中位数无进展生存 (PFS) (22.0个月) 和总生存 (OS) (61.3个月).
- 同步治疗是PFS (HR=0.493) 和OS (HR=0.211) 的独立保护因素.
- 瘤大小≥3厘米和周周膜位置是局部进展的风险因素;瘤负担,肺外转移和中枢淋巴结参与影响了OS.
结论:
- 与TA相结合的同步全身疗法可显著改善潜在可治愈的CRLM患者的PFS和OS.
- 系统治疗的时间是管理CRLM的关键因素.
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