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完整血清参数作为儿童炎症性肠病疾病表型的预测因素
Ahsen Donmez Turkmen1, Gizem Tanalı2, Alican Sarısaltık3
1Department of Pediatric Gastroenterology, Hepatology and Nutrition, Marmara University Faculty of Medicine, İstanbul, Türkiye.
Journal of pediatric gastroenterology and nutrition
|January 6, 2026
概括
完整血清 (CBC) 指数可以预测儿科性结肠炎和克罗恩病的疾病严重程度. 诊断时较低的绝对淋巴细胞数量和淋巴细胞对单细胞的比率表明克罗恩病的严重程度更高.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 血液学 血液学 血液学
- 炎症性肠道疾病研究研究
背景情况:
- 完整血清 (CBC) 是一种常规的,具有成本效益的测试.
- 它在评估儿科炎性肠病 (IBD) 现型和活性方面的实用性需要进一步研究.
研究的目的:
- 确定CBC指数是否可以帮助评估儿科IBD诊断时的疾病表型和活性.
- 确定CBC参数,预测克罗恩病 (CD) 中的疾病行为.
主要方法:
- 在120名儿科IBD患者 (UC/CD) 和120名对照患者中比较了CBC指数 (包括NLR,LMR,NMR,ALC).
- 使用ROC分析和Youden指数在预测CD行为时找到ALC和LMR的最佳切断值.
- 采用多变量逻辑回归来评估独立关系并预测CD行为.
主要成果:
- IBD患者的白细胞,血小板,中性粒细胞,单细胞计数和NLR比对照人群高.
- 慢性病患者的绝对淋巴细胞计数 (ALC) 比UC和对照组明显低.
- 降低ALC和LMR是严格的,透的和围性CD的显著预测因素.
结论:
- 诊断时的CBC指数可以评估儿科IBD中的UC严重程度和CD行为.
- 这些发现凸显了CBC在预测IBD疾病表型方面的潜在作用.
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