检查代谢肥胖表型与心力衰竭风险亚型之间的关联
Jiancheng Zhang1,2, Bin Dong1,2, Jiayong Li1,2
1Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China.
American journal of preventive cardiology
|January 6, 2026
概括
代谢不健康的肥胖 (MUO) 和代谢不健康的非肥胖 (MUNO) 会增加心力衰竭的风险. 代谢健康的肥胖症 (MHO) 与心力衰竭有关,具有保存的喷射分数 (HFpEF),但没有减少的喷射分数 (HFrEF/HFmrEF).
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 肥胖和代谢功能障碍是不同的,但它们对心力衰竭 (HF) 亚型的联合影响仍然不清楚.
- 了解这些关系对于有针对性的预防和治疗策略至关重要.
研究的目的:
- 调查不同代谢肥胖表型之间的关联以及未来发展特定心力衰竭亚型的风险.
- 分析随着时间的推移,表型之间的转变如何影响心力衰竭风险.
主要方法:
- 利用了ARIC研究中的9791名参与者的数据.
- 他们将参与者分为四种表型:代谢健康的非肥胖 (MHNO),代谢健康的肥胖 (MHO),代谢不健康的非肥胖 (MUNO) 和代谢不健康的肥胖 (MUO).
- 采用考克斯回归模型来评估具有保留射出分数 (HFpEF) 和具有减少或中等射出分数 (HFrEF/HFmrEF) 的HF风险.
主要成果:
- 与MHNO相比,MHO,MUNO和MUO表型与增加的HFpEF风险有关.
- MUNO和MUO表型显示HFrEF/HFmrEF的风险增加.
- 关联在55岁以下的个人和女性中更为明显. 持久不健康的表型 (MHO, MUNO, MUO) 增加了HFpEF风险,而过渡到MUO则增加了所有HF亚型的风险.
结论:
- 代谢不健康的非肥胖 (MUNO) 和代谢不健康的肥胖 (MUO) 与所有心力衰竭亚型的风险增加有关.
- 代谢健康的肥胖 (MHO) 特别与HFpEF风险增加有关,但不是HFrEF/HFmrEF.
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