AnchorDrug:一种通过积极学习在新环境中预测药物诱导的基因表达的系统
Han Meng1, Ruoqiao Chen1, Bin Chen1
1Michigan State University.
概括
选择最佳的实验样本对于复杂的生物系统中少量学习至关重要. AnchorDrug利用主动学习来识别关键药物,改善基因表达预测模型,即使数据有限.
科学领域:
- 生物医学信息学 生物医学信息学
- 计算生物学 计算生物学
- 机器学习在生物学中的应用
背景情况:
- 大型预训练模型面临着各种生物系统的零射击学习的挑战.
- 短暂的学习通常依赖于有限的实验数据,但最佳样本选择方法未得到充分探索.
- 药物诱导的基因表达预测是一项复杂的任务,需要有效的数据采集策略.
研究的目的:
- 开发一种基于数据的方法,用于对生物医学任务进行少量学习的样本选择.
- 创建一个系统,AnchorDrug,用于预测新细胞系中药物诱导的基因表达变化.
- 优化实验药物 (药物) 的选择,以便在微调过程中最大限度地提高模型性能.
主要方法:
- 使用大量药物诱导基因表达的数据集开发了一种预训练模型.
- 实施了主动学习与定制的获取功能,以确定最佳的药物.
- 微调了模型,使用来自选择基药物的实验数据来预测药物诱导的基因表达.
主要成果:
- 定制的积极学习方法在识别有效的药物方面超过了基于知识的药物选择.
- 用基药物数据训练的模型取得了卓越的表现,有时超过了所有可用数据训练的模型.
- 提供了对驱动药物方法增强性能的机制的见解.
结论:
- 在生物医学研究中,AnchorDrug提供了一种有效的样本选择策略,用于几次拍摄的学习场景.
- 基于主动学习的药物选择可以显著提高基因表达预测模型的性能.
- 该系统旨在在现实世界生物医学研究项目中实践应用,优化实验资源配置.
更多相关视频
03:08Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
Published on: October 3, 2025
893
08:04Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
Published on: June 6, 2025
1.4K
相关概念视频
Drug Discovery: Overview
10.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.9K
Structure-Activity Relationships and Drug Design
1.7K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.7K
Targets for Drug Action: Overview
10.0K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
10.0K
Drug Dependence
1.6K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.6K
Improving Translational Accuracy
14.1K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
14.1K
Improving Translational Accuracy
3.5K
3.5K
