在正常单光子发射计算机断层扫描扫描患者中异常冠状动脉计算机断层扫描血管的预测值
Rami M Abazid1, Monerah A Almohideb2, Mohammad A Barry2
1Division of Cardiology, Department of Medicine, Sault Area Hospital, Sault Ste Marie, Northern Ontario School of Medicine (NOSM) University, Ontario, P6B 0A8, Canada.
异常冠状动脉计算机断层扫描血管学 (CCTA) 发现预测正常单光子发射计算机断层扫描 (SPECT) 扫描的患者的主要不良心脏事件 (MACE). 在CCTA上阻塞性冠状动脉疾病 (CAD) 表明MACE的长期风险较高.
科学领域:
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 评估冠状动脉计算机断层扫描血管学 (CCTA) 的预后价值,在单光子发射计算机断层扫描 (SPECT) 结果正常的患者中.
- 当SPECT结果不确切或正常时,评估CCTA的风险分层能力.
研究的目的:
- 确定异常的CCTA发现,特别是阻塞性冠状动脉疾病 (CAD),是否预测正常SPECT结果的患者的主要不良心脏事件 (MACE).
- 为了比较CCTA上阻塞性与非阻塞性CAD患者的长期结果,尽管正常的SPECT.
主要方法:
- 对1558名正常的SPECT扫描和异常的CCTA患者的回顾性分析.
- 根据CCTA,将患者分为阻塞性 (≥50%狭窄) 和非阻塞性 (<50%狭窄) CAD组.
- 对主要不良心脏事件 (MACE) 的随访,定义为心血管死亡和非致命的心肌梗塞.
主要成果:
- 与非阻塞性CAD患者 (87.1%) 相比,患有阻塞性CAD患者 (12.9%) 的患者年龄较大,男性更频繁,糖尿病发病率更高.
- 尽管正常的SPECT,阻塞性CAD与明显更高的MACE率 (12.4%对4.8%,p<0.001) 有关.
- 多变量分析确定了阻塞性CAD (HR 2.57,p<0.001) 作为死亡率的独立预测因素,以及年龄,糖尿病和冠状动脉分数.
结论:
- 异常的CCTA发现,特别是阻塞性冠状动脉疾病 (CAD),在正常SPECT患者中具有显著的预后价值.
- 与非阻塞性CAD相比,CCTA上的阻塞性CAD在这个患者队列中发现了较高的重大心脏不良事件 (MACE) 的长期风险.
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