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味觉受体位置的变异与失眠药物的使用变化有关
Gudmundur Einarsson1, Hannes K Arnason1,2, Rosa S Gisladottir1,3
1Amgen deCODE Genetics, Reykjavik, Iceland.
Biological psychiatry global open science
|January 6, 2026
概括
苦味受体基因中的一个遗传变异 (rs6488335-G) 影响了 zopiclone 和 zolpidem 之间的切换. 这一发现可能会个性化失眠药物处方,特别是对于女性来说,以改善治疗坚持.
科学领域:
- 药物遗传学 药物遗传学
- 基因组学就是基因组学.
- 个性化医疗是个性化的医疗.
背景情况:
- 佐皮克隆和佐尔皮德姆是常见的失眠药物,具有相似的疗效但不同的副作用.
- 味觉障碍是一个显著的副作用,影响患者的坚持.
- 识别遗传因素可以优化个性化的失眠治疗策略.
研究的目的:
- 进行全基因组关联研究 (GWAS),以找到转换佐皮克隆和佐尔皮之间的遗传预测因素.
- 调查大队伍中遗传变异和切换模式之间的关联.
- 探索遗传变异,味觉感知和药物切换之间的关系.
主要方法:
- 用电子处方数据对57,669名冰岛人和6590名英国人进行了GWAS.
- 包括至少有三次索皮克隆或佐尔皮的处方的人.
- 来自2238名冰岛人的苦味感知数据与遗传数据一起分析.
主要成果:
- 一种常见的变异,rs6488335-G,靠近TAS2R苦味受体基因,与从佐皮克隆切换到佐尔皮德姆的增加有关.
- 这种关联在冰岛和英国队列中都被观察到,在女性中更为明显.
- 虽然与苦味感知有关,但该变体对药物切换的影响似乎独立于味觉敏感性.
结论:
- rs6488335-G变异可能预测对佐皮克隆的不耐受性,导致切换到佐皮德姆,特别是在女性中.
- 基因检测可以预先识别可能经历味道相关副作用的个体.
- 基于遗传特征的个性化处方可能会降低医疗保健利用率并提高治疗遵守率.
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