人类呼吸道器官中HAdV-14p1的热带性,复制能力和细胞反应
Wenyu Guo1,2, Yihao Yang1,2, Ying Liang1,2
1Department of Laboratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
iScience
|January 6, 2026
概括
人类腺病毒14p1型 (HAdV-14p1) 导致严重的呼吸系统疾病. 人类呼吸道器官显示HAdV-14p1感染多种细胞类型并引发炎症,但cidofovir有效抑制病毒复制.
科学领域:
- 病毒学 病毒学
- 细胞生物学 细胞生物学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 人类14p1型腺病毒 (HAdV-14p1) 是严重呼吸系统疾病的重要原因.
- 了解HAdV-14p1的发病过程需要详细了解它与宿主细胞的相互作用.
研究的目的:
- 描述HAdV-14p1在人类呼吸道有机体中的细胞热带和感染动态.
- 为了研究宿主细胞对HAdV-14p1感染的反应.
- 为了评估cidofovir对HAdV-14p1.1.的抗病毒疗效.
主要方法:
- 利用人类呼吸道器官来模拟HAdV-14p1感染.
- 分析了细胞热带性,病毒复制动力学和基因表达变化.
- 对差异表达基因进行了途径丰富分析.
- 评估了基多福维尔治疗对病毒复制和细胞毒性的影响.
主要成果:
- HAdV-14p1在人类呼吸道器官中表现出强大的感染和复制,向状细胞,基底细胞和杯状细胞.
- 炎症基因 (CCL5,CXCL10,CXCL11,TNFSF13B) 的显著上调和p53信号的丰富,细胞因子-细胞因子受体相互作用和NOD类受体信号通路.
- 参与焦点粘附,紧密结合,新陈代谢和氧化酸化的基因的下调.
- 齐多福维尔有效地抑制了HAdV-14p1复制,细胞毒性最小.
结论:
- HAdV-14p1表现出强大的复制性,并诱导一种促炎性反应,为其病变产生作出贡献.
- 人类呼吸道有机体是研究HAdV-14p1-宿主相互作用的宝贵模型.
- 齐多福维尔作为一种有效的抗病毒药物对抗HAdV-14p1.1.
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