在没有并发症的双胞胎怀孕妇女中,24小时尿蛋白分泌的参考间隔
Yuguo Deng1,2, Lanyun Liu1,2, Danxiu Lu1,2
1Department of Obstetrics, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City, Shenzhen, Guangdong, China (Deng, Liu, Lu, Wu, and Yang).
AJOG global reports
|January 6, 2026
概括
现在已经确定了双胞胎怀孕中24小时尿道总蛋白 (24-h UTP) 的参考间隔. 双胞胎怀孕显示24小时UTP水平明显高于单胎从第二个三个月开始.
科学领域:
- 产科和妇科 产科和妇科
- 腎臟病學 (nephrology) 是一種醫學.
- 临床化学 临床化学
背景情况:
- 24小时尿道总蛋白 (24-h UTP) 对于评估功能和妊娠并发症至关重要.
- 有限的数据存在于24小时UTP参考间隔,专门用于双胞胎怀孕.
研究的目的:
- 在双胞胎怀孕的妇女中建立24小时UTP的参考间隔.
- 将这些间隔与携带单子的女性的间隔进行比较.
主要方法:
- 招募了12633名单身或双胞胎怀孕的参与者.
- 收集了24小时的尿样,并从电子病历中提取了数据.
- 使用非参数百分位数方法来确定跨季度的参考间隔,不包括特定的高风险条件.
主要成果:
- 双胞胎怀孕的24小时UTP水平在整个妊娠期间显著增加 (P<.001).
- 双胞胎怀孕 (第1,2,3个季度) 的24小时UTP中位数分别为74.2,104.5和152.6毫克.
- 在双胞胎怀孕中观察到显著更高的24小时UTP分泌量,而在第二和第三季度的单子怀孕中则相比较高 (P<.001).
结论:
- 在双胞胎怀孕中,24小时UTP水平从怀孕早期到晚期大约翻了一番.
- 在晚期双胞胎怀孕中,正常24小时UTP的上限是415.7毫克.
- 较高的蛋白尿值在双胞胎怀孕中可能更高,从第二个三个月开始,需要量身定制的管理和咨询.
相关概念视频
Nephrotic Syndrome II : Assessment and Medical Management
189
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
189
Serum Studies: Renal Function Tests
357
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
357
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
176
In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
176
Urine Studies I: Urinalysis
1.1K
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
1.1K
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
182
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
182
Pharmacokinetics in Pediatric Patients: Drug Excretion
201
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
201


