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定制人类关节芯片:从生物原理,材料,到疾病建模

Xuejiao Wang¹, Louis Jun Ye Ong^2,3,4,5, Marcel Karperien⁶

¹Department of Biomedical Engineering, Research Institue of Smart Ageing, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.

Materials today. Bio

|January 6, 2026

概括

芯片上的关节 (JoC) 模型提供了一个微流体平台,用于研究关节健康和疾病. 未来JoC技术的进步将加速药物发现和针对关节疾病的个性化医疗.

科学领域:

生物医学工程生物医学工程
微流体学微流体学
组织工程是组织工程.
类风湿病学类风湿病学

背景情况:

芯片上的关节 (JoC) 是一个采用微流体和组织工程的小型化体外模型.
联合医院的目标是研究关节生理学和病理学,推进个性化医学.
生物仿真JoC工程需要复制生理架构,生物机械环境和系统风险因素.

研究的目的:

提供关于芯片上的联合 (JoC) 技术的全面概述.
弥合工程师,生物学家和临床医生之间的知识差距.
总结高级JoC平台的关键设计因素,材料和制造技术.

主要方法:

综合生物学基础的审查.
对JoC基本特征和设计考虑的分析.
在芯片制造和微型制造技术中使用的材料的分类.
对现有的JoC平台进行疾病特异性分析的评估.

主要成果:

材料科学和微型制造的最新进展使复杂的JoC开发成为可能.
目前的JoC平台有助于针对性调查和关节疾病的高准确度建模.
在现有平台中采用简化,缩小主义的组织相互作用系统.

结论:

未来的JoC开发需要在细胞共同培养,自动控制和实时监控方面取得进展.
克服这些挑战将大大加快JoC在基础研究中的应用.
成功实施JoC将加速药物发现和针对关节疾病的个性化医疗.

关键词:

细胞共同培养的细胞共同培养.疾病建模疾病建模关节疾病关节疾病在芯片上的联合.微流体学微流体学

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