[系统性免疫-炎症指数与动脉样硬化之间的相关性:基于健康检查人口的交叉-截面研究]
Ruiqi Liu1,2, Qiongmei Fu3,4, Wei Zhou5,6
1Health Management Center, Xiangya Hospital, Central South University, Changsha 410008. rickyliu1013@126.com.
概括
系统性免疫炎症指数 (SII) 与动脉样硬化 (CAS) 风险有关,但这种关联在性别之间存在显著差异. 高SII独立预测女性的CAS,而在男性中,它通过炎症细胞调解起作用.
科学领域:
- 心血管疾病研究研究
- 炎症和免疫学 炎症和免疫学
- 生物标志物发现发现
背景情况:
- 动脉样硬化 (CAS) 是中风的重要危险因素,慢性血管炎症在其发展中发挥着关键作用.
- 系统性免疫炎症指数 (SII) 是系统性炎症的标志物,已成为各种疾病的潜在指标.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 和大脑动脉动脉样硬化 (CAS) 之间的关联.
- 分析SII-CAS关系中的性别特异性差异.
- 为动脉样硬化的早期预防和控制策略提供证据.
主要方法:
- 一个单一中心的横截面研究涉及19788名参与者,他们接受了带超声波评估.
- 参与者根据CAS的存在或不存在被分类为组,并按SII四分位数分层.
- 根据性别分层的后勤回归和调解分析被用于评估关联,并确定介导因素,如白细胞和单细胞计数.
主要成果:
- 较高的SII与增加的CAS风险有关,特别是在女性中,在所有模型中,这种关联仍然显著.
- 在男性中,SII和CAS之间的关联主要由白细胞和单细胞计数介导.
- 虽然SII通过炎症细胞调解影响男性的CAS,但它代表了女性的独立相关物,具有直接影响.
结论:
- 在SII和CAS之间的关联中存在显著的性别特异性.
- 高SII是女性CAS的独立预测因素,不受常见炎症细胞计数的介导.
- 在男性中,SII主要通过白细胞和单细胞的调解来影响CAS,这表明风险评估和干预的性别向方法.
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