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在新加坡宫样本中高风险人类乳头瘤病毒基因型的流行:对临床管理的影响

Vivekanathan Nandakumar¹, Satheeskumar Krishnan¹, Chia-Pin Chang¹

¹iGene Laboratory Private Limited, Singapore.

Annals of the Academy of Medicine, Singapore

|January 6, 2026

概括

在新加坡的综合性人类乳头瘤病毒 (HPV) 基因型鉴定发现HPV52和58是最常见的. 美国镜和宫病理学会 (ASCCP) 的指导方针与当地指导方针相比,减少了不必要的程序.

科学领域:

在瘤学瘤学.
病毒学病毒学
公共卫生公共卫生

背景情况:

人类乳头瘤病毒 (HPV) 是导致超过95%的宫癌的原因.
目前的宫癌查指南,例如美国宫透镜和宫病理学会 (ASCCP) 的指南,主张基于风险的方法.
这种方法利用信息化测试,可能包括高风险 (HR) HPV 基因型鉴定,尽管许多实验室只进行部分基因型鉴定.

研究的目的:

报告来自新加坡人口的宫样本中所有14种HR HPV基因型的综合基因定型的发现.
检查基因型流行率和细胞学相关性.
为了比较新加坡宫透镜和宫病理学会 (SCCPS) 的指导方针与ASCCP 2019指导方针下的随访管理.

主要方法:

总共分析了2497个宫样本,使用实时聚合酶连锁反应进行完整的HPV基因定型.
对HPV阳性病例 (327例/2497例) 进行了基因型流行率和细胞学相关性分析.
在SCCPS和ASCCP 2019指南中,对初级查和联合测试情景进行了管理策略的比较.

主要成果:

HPV52和58是最常见的基因型,占所有检测到的HR HPV基因型的32.2%.
在20.2%的样本中存在并发感染. 在HPV16/18阳性病例 (9.5%) 中,大多数病例细胞质正常.
应用ASCCP初级查指南可以使16.8%的病例在1年内推迟立即细胞检查以重复HPV检测. 在共同测试中,ASCCP的指导减少了7.4%的镜转诊.

结论:

综合性HPV基因型鉴定提高了风险分层和患者管理效率.
与SCCPS相比,ASCCP指南减少了不必要的程序,同时保持了安全.
在新加坡的宫部查计划中,支持更广泛地采用完整的基因型和基于风险的分类.

关键词:

癌症癌症癌症癌症癌症流行病学流行病学高风险的HPV基因定型传染病是一种传染性疾病.产科和妇科产科和妇科瘤学在瘤学方面.

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