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Updated: Jan 13, 2026

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
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Published on: December 30, 2025

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面向DNA结合的全长p53四聚体的局部动力学

Özlem Demir1, Emilia P Barros1, Rommie E Amaro2

  • 1Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, San Diego, California 92093, United States.

Journal of chemical information and modeling
|January 6, 2026
PubMed
概括

恢复瘤抑制剂p53 (也称为TP53) 的活性是一个有前途的癌症治疗策略. 这项研究模拟了全长的p53四聚合物,揭示了其DNA相互作用和动态,并确定了新的潜在药物标.

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