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对生物机械反应的形态有限元素L4-L5功能脊柱单元的灵敏度分析

Subin George¹, Krishnan Venkatesh², Gurunathan Saravana Kumar¹

¹Department of Engineering Design, IIT Madras, Street, Chennai, 600036, Tamil Nadu, India.

Journal of biomechanical engineering

|January 6, 2026

概括

腰椎的形态变化显著影响生物力学反应. 横径和圆盘角等关键特征对于理解脊柱单元功能和预防伤害至关重要.

科学领域:

生物力学生物力学
脊椎解剖学脊椎解剖学
计算机建模计算建模

背景情况:

静态脊椎模型缺乏针对个性化医学和伤害预防的预测能力.
在体外实验面临的局限性是由于研究群体的形状变化最小.

研究的目的:

评估人类特征对L4-L5腰椎功能脊柱单元 (FSU) 生物机械反应的敏感性.
为了确定影响FSU生物力学的关键形态参数,在动量负载下.

主要方法:

使用OFAT和CLHS采样设计实验 (DoE) 框架生成了一个L4-L5FSU群体.
使用ANSA BETA CAE TM.应用的人类测量变化 (圆盘,直径,脊椎高度,面角).
使用皮尔森相关系数和线性回归进行了灵敏度分析.

主要成果:

横径和前后直径显示出与运动范围 (ROM) 的强烈负相关性.
磁盘角与面接触力有很强的正相关性.
确定了影响生物力学反应的关键人体参数,如ROM,磁盘压力和面接触力.

结论:

形态变异显著影响腰部功能脊柱单元生物力学.
横直径,前后直径和磁盘角是生物力学反应的关键预测因素.
这些发现与现有的体外数据一致,支持脊柱研究的形态模型的实用性.

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