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肠道微生物群作为积极青年发展过渡从童年到青春期早期的预测因素:一个队列研究
Yujie Xu1, Xiaoyu Wang1, Mengxue Chen1
1Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Children's Medical Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China.
肠道微生物组预测儿童的积极青年发展 (PYD) 过渡. 特定的肠道细菌和富含水果和蔬菜的饮食与青春期稳定或改善的PYD有关.
科学领域:
- 儿科健康 儿科健康
- 微生物组研究 微生物组研究
- 青少年发展 青少年发展
背景情况:
- 儿童心理健康越来越多地与肠道微生物组有关.
- 阳性青年发育 (PYD) 受肠道微生物组成的影响.
- 了解PYD过渡及其预测因素对于儿童福祉至关重要.
研究的目的:
- 描述从童年到青春期的积极青年发展 (PYD) 过渡的模式.
- 调查肠道微生物组对这些PYD过渡的预测价值.
- 探索饮食对肠道微生物群和PYD的影响.
主要方法:
- 一项纵向队列研究分析了661名8至11岁儿童的数据.
- 潜伏过渡分析确定了PYD配置文件 (降级,晋升,稳定).
- 16S rRNA测序描述了肠道微生物组;机器学习模型预测了PYD过渡.
主要成果:
- 确定了三个PYD过渡档案:降级,晋升和稳定.
- 15个微生物属预测了PYD过渡,其中较高的丰度与稳定或促进的个人资料相关 (OR 2.03-5.45).
- 一个预测模型实现了0.91的AUC;协会在早期青春期更强烈,并且与含水果,蔬菜和大豆高的饮食有关.
结论:
- 肠道微生物组显著预测了从童年到青春期的PYD过渡.
- 针对特定的肠道微生物种群可能会增强儿童发育计划.
- 干预措施应考虑肠道微生物群,特别是在青春期.
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