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Updated: Jan 13, 2026

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
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Published on: September 23, 2021

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通过双量子连贯电子自旋共振方法检测突变诱导的内在无序蛋白质的形态变化

Aritro Sinha Roy1,2, Karen Tsay3, Peter P Borbat1,2

  • 1Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853-1301, United States.

Journal of the American Chemical Society
|January 6, 2026
PubMed
概括

电子自旋共振 (ESR) 脉冲二极光谱使用双量子连贯性 (DQC) 精确地绘制蛋白质结构. 这种方法揭示了野生型和突变型tau蛋白碎片之间的明显构造差异,有助于神经退行性疾病研究.

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