支气管透视检查识别了学龄前儿童具有难治性呼吸道症状的细菌气道殖民和并发症:一项回顾性研究
Helena Donath1, Julius Ruff1, Laura Heumüller1
1Department of Pediatrics, Division of Pneumology, Allergology, Infectious Diseases and Gastroenterology, Goethe University Frankfurt, Frankfurt am Main, Germany.
Pediatric pulmonology
|January 6, 2026
概括
支气管镜能有效地诊断学龄前儿童的持续性呼吸问题. 细菌的呼吸道殖民是常见的,与支气管洗液 (BAL) 中的中性粒细胞数量较高有关.
科学领域:
- 儿科肺病学 儿科肺病学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 患有持续呼吸道症状的学龄前儿童通常需要诊断支气管镜检查.
- 支气管支气管洗 (BAL) 有助于检测下呼吸道感染.
- 这项研究调查了BAL发现,细菌殖民和相关的并发症.
研究的目的:
- 分析学龄前儿童的BAL液体检测结果,这些儿童有难治性呼吸道症状.
- 确定细菌殖民,过敏状态,以及诸如GERD和EOE之类的并发症之间的关联.
- 评估支气管镜在这个人群中的诊断效用.
主要方法:
- 355名儿童 (1-5岁) 经过支气管镜检查 (2010-2019) 的回顾性分析.
- 对BAL差异性细胞学和细菌培养的评估.
- 实验室参数的分析,食道胃二透镜 (OGDS) 和食道活检组织学.
主要成果:
- 细菌培养在61.7%的儿童中呈阳性;Hemophilus influenzae,Streptococcus pneumoniae和Moraxella catarrhalis是最常见的.
- 阳性细菌培养与BAL液中中性粒细胞百分比显著更高的相关性.
- 胃食道逆流性疾病 (GERD) 在32%的儿童中存在,而性食道炎 (EoE) 在2.8%的儿童中存在.
结论:
- 支气管检查是诊断学龄前儿童持续性呼吸道症状的宝贵工具.
- 在这个群体中,细菌殖民是常见的,并且与呼吸道中性粒细胞增加有关.
- 在评估中应考虑诸如GERD和EoE之类的并发症.
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