阻塞性睡眠呼吸暂停与双边原发性阿尔多斯特隆症比单边原发性阿尔多斯特隆症更密切相关
Wenwen He1, Liping Zan1, Yue Sun1
1Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Street, Chongqing, 400016, China.
Journal of endocrinological investigation
|January 6, 2026
概括
阻塞性睡眠呼吸暂停 (OSA) 与双边原发性阿尔多斯特隆症 (BPA) 密切相关,BPA患者的患病率和严重程度较高. 在原发性阿尔多斯特症患者,特别是BPA患者中,查OSA对于更好的健康结果至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 睡眠医学 睡眠医学
- 心血管健康 心血管健康
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 被怀疑在原发性阿尔多斯特主义 (PA) 病理生理学中发挥作用.
- 骨质疏松症和双边原发性阿尔多斯特症 (BPA) 之间的特定关系需要进一步调查,以改善患者管理.
研究的目的:
- 为了确定OSA和BPA之间的独立关联.
- 为了比较单边原发性阿尔多斯顿症 (UPA) 和BPA患者之间的临床和睡眠特征.
主要方法:
- 一组136名PA患者 (79名UPA,57名BPA) 接受了临床,生化和多睡眠学评估.
- 分析了OSA的患病率和严重程度,并在UPA和BPA组之间进行了比较.
- 使用后勤回归模型来评估OSA和BPA之间的关联.
主要成果:
- 与UPA患者相比,BPA患者的体重,BMI,腰围,甘油三,血清和血原蛋白度较高.
- BPA患者的呼吸暂停-呼吸暂停指数 (AHI) 较高,呼吸暂停阻塞性较多,睡眠期间氧和度较低.
- 中度至重度的OSA在BPA中比UPA (48%) 更为普遍 (61%),OSA与BPA独立相关 (调整后OR为9.91).
结论:
- OSA与BPA的风险增加有显著的相关性.
- 与UPA相比,OSA在BPA患者中更为普遍和严重.
- 建议对PA患者进行常规的OSA查,特别是那些患有BPA患者,以减轻心血管风险.
相关概念视频
Sleep Apnea
469
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
469
Adrenergic Antagonists: Pharmacological Actions of ɑ-Receptor Blockers
1.4K
α-Adrenergic antagonists, known as α-blockers, exert their effects by inhibiting α-adrenoceptors, leading to specific physiological actions. α1-blockers and α2-blockers have distinct pharmacological actions and therapeutic applications.
α1-blockers: These drugs inhibit α1-adrenoceptors on smooth muscle cells, resulting in vasodilation. This vasodilation lowers blood pressure, making α1-blockers valuable in treating hypertension. Additionally,...
α1-blockers: These drugs inhibit α1-adrenoceptors on smooth muscle cells, resulting in vasodilation. This vasodilation lowers blood pressure, making α1-blockers valuable in treating hypertension. Additionally,...
1.4K
Adrenal Gland Disorders
2.9K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
2.9K
Antihypertensive Drugs: Direct Renin Inhibitors
1.3K
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
1.3K
Antihypertensive Drugs: Action of β1 Blockers
1.9K
β1-receptors are primarily located in the heart and kidneys. In cardiac myocytes, these receptors interact with neurotransmitters released by the sympathetic nervous system during heightened activity or danger. As a result, β1-receptors get activated, initiating a series of biochemical processes. Excessive activation of beta receptors due to chronic stress can abnormally increase heart rate and contractility, resulting in high blood pressure or hypertension. To counteract this,...
1.9K
Antihypertensive Drugs: Potassium-Sparing Diuretics
2.2K
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
2.2K


