脊髓损伤和疾病作为缺血性中风的危险因素:美国退伍军人的五年回顾性队列研究
Rafer Willenberg1,2,3,4, Bridget M Smith5, Kevin T Stroupe6,7
1VA Boston Healthcare System, Boston, MA, USA. rafer.willenberg@va.gov.
Journal of neurology
|January 6, 2026
概括
脊髓损伤和疾病 (SCI/D) 在美国退伍军人中增加缺血性中风风险. 对于四肢,非创伤性SCI/D以及年轻人来说,这种风险更高.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 以前的研究表明,脊髓损伤和疾病 (SCI/D) 与缺血性中风风险增加之间存在联系.
- 然而,现有的研究受限于稀疏的数据,相互矛盾的结果,缺乏SCI/D特异性分析和小样本大小.
研究的目的:
- 调查SCI/D是否代表缺血性中风的危险因素.
- 为了确定与SCI/D相关的特定相关关系,有助于中风风险.
主要方法:
- 一项回顾性研究分析了2017-2021年美国退伍军人健康管理局和医疗保险数据.
- 普森回归模型估计了有SCI/D和没有SCI/D的退伍军人的首次中风发病率,并对共变量进行了调整.
主要成果:
- 与对照人群相比,患有SCI/D的退伍军人中风发生率高出19%.
- 对四肢 (50%更高),非创伤性SCI/D (36%更高) 和年轻的退伍军人 (<40岁,125%更高) 观察到更高的风险.
- 创伤性脊髓损伤与中风发病率的增加没有显著的关联.
结论:
- 证实SCI/D是美国退伍军人中缺血性中风的危险因素.
- 四肢,非创伤性SCI/D和年轻年龄是与此人群中风风险升高相关的关键因素.
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