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在接受氧化治疗的患者的光学连贯性断层扫描血管学参数

Hui Di Khor^1,2, Jun Fai Yap^1,3, Yi Wen Lim¹

¹UM Eye Research Centre, Department of Ophthalmology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.

International ophthalmology

|January 6, 2026

概括

长期使用氧化 (HCQ) 显示了对和外区域的视网膜变薄. 光学连贯断层扫描血管造影 (OCTA) 可以检测这些早期的HCQ诱导的视网膜变化.

科学领域:

眼科医生眼科眼科
视网膜成像视网膜成像
药理学研究药理学研究

背景情况:

氧化 (HCQ) 广泛用于自身免疫性疾病.
长期使用HCQ可能导致视网膜毒性.
早期检测视网膜变化对于患者管理至关重要.

研究的目的:

评估长期HCQ使用者 (≥5年) 中的亚临床视网膜微血管变化.
为了比较HCQ用户和使用OCTA的健康对照组之间的视网膜参数.
评估OCTA在早期识别HCQ诱导的视网膜变化的潜力.

主要方法:

一项涉及59名HCQ使用者和59名对照者的病例控制研究.
光学连贯断层扫描血管造影 (OCTA) 用于评估形无血管区 (FAZ),表面和深层毛细血管 (SCP和DCP) 的黄斑血管密度 (VD),以及视网膜厚度.
统计分析包括独立的t测试,曼-惠特尼U测试和斯皮尔曼等级相关性.

主要成果:

两组之间FAZ面积或中央骨厚度 (CFT) 没有显著差异.
在HCQ使用者 (p<0.001) 中观察到显著的偏和外视网膜稀释 (p<0.001).
在HCQ使用者的foveal和parafoveal深毛细管 (DCP) 中显著更高的斑点VD (p<0.001).

结论:

长期使用HCQ与显著的偏和外视网膜稀释有关.
在长期使用HCQ的患者中,OCTA发现了可变的微血管变化.
在早期检测HCQ诱导的视网膜改变方面,OCTA显示出有前途.

关键词:

的非血管区是的非血管区.氧化chloroquine 的使用情况.光学连贯性断层扫描仪光学连贯性断层扫描血管图谱船舶密度船舶密度船舶密度

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