缓解的时间和类固醇剂量在老年和年轻的多肌痛类风湿患者
Sibel Ösken1,2, Mehmet Engin Tezcan3
1Department of Rheumatology, Istanbul Erenköy Physical Therapy and Rehabilitation Hospital, Merdivenköy, Ressam Salih Erimez Cad No: 21, 34732, Kadiköy/Istanbul, Türkiye. sibeltos@yahoo.com.
European geriatric medicine
|January 6, 2026
概括
与年轻人相比,老年多发性肌痛性风湿症 (PMR) 患者的缓解缓解,即使服用类似的类固醇剂量. 老年患者中性粒细胞数量升高可能表明一种促炎状态,有助于持续的疾病活动.
科学领域:
- 类风湿病学 类风湿病学
- 老年医学 老年医学
- 临床免疫学临床免疫学
背景情况:
- 多发性肌痛性风湿症 (PMR) 是一种常见的炎症状况,主要影响50岁以上的人.
- 了解PMR呈现和治疗反应的年龄相关差异对于优化患者护理至关重要.
研究的目的:
- 为了比较缓解的时间,葡萄糖皮质类药物剂量和年龄较大与年轻的多肌痛类风湿症患者的临床特征.
- 为了确定与不同年龄组延迟缓解相关的因素.
主要方法:
- 对157名多发性肌痛类风湿患者进行了回顾性队列研究.
- 分为老年人 (≥65岁) 和年轻人 (<65岁) 的分层.
- 人口统计,并发症,实验室发现和治疗结果的比较,重点是缓解时间和类固醇剂量.
主要成果:
- 老年患者 (平均年龄75.8岁) 与年轻患者 (平均年龄60.2岁,4.0个月) 相比,缓解的时间显著更长 (5.1个月).
- 在老年人群中观察到更高的中性粒细胞数量和超脂血的患病率增加.
- 缓解所需的葡萄糖皮质激素剂量在年龄组之间是可比的.
- 年龄和中性粒细胞数被确定为延迟缓解的独立预测因素.
结论:
- 患有多发性肌痛性风湿症的老年患者的缓解速度比年轻患者慢,尽管接受了同等的葡萄糖皮质类药物治疗.
- 老年人中中性粒细胞数量增加可能意味着与年龄相关的炎症过程延长了疾病活动.
- 开发适应年龄的治疗策略是有必要的,以改善老年PMR患者的治疗结果.
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