分析SARS-CoV-2感染对大学生免疫功能和代谢变化的影响
Fengzhi Li1, Yijin Zan2, Yukun Cao1
1Department of Respiratory and Critical Care Medicine, Air Force Medical Center, Beijing, China.
概括
在接种疫苗的学生中,COVID-19 Omicron感染会导致持久的免疫和代谢变化,两年后恢复不完全. 监测淋巴细胞和代谢标记是管理COVID-19后长期影响的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢健康 代谢健康
- 病毒学 病毒学
背景情况:
- 在接种疫苗的人群中,COVID-19的长期免疫和代谢后果尚未完全理解.
- 之前的疫苗接种情况和Omicron变种感染影响需要进一步调查.
研究的目的:
- 分析Omicron感染后大学生淋巴细胞亚群 (T,B和自然杀伤细胞) 和代谢指标的动态变化.
- 描述感染后两年的免疫和代谢恢复轨迹.
主要方法:
- 对71名感染Omicron变种的男学生和18名对照进行前性观察队列研究.
- 在感染后3,6,12和24个月对TBNK子集和代谢参数 (尿酸,脂质,β2-微球蛋白) 的分析.
主要成果:
- 在T细胞,NK细胞和B细胞中观察到显著的波动,B细胞显示持续下降.
- 包括尿酸和脂质配置文件在内的代谢参数在一年内显著增加.
- 在24个月的随访期间,β2-微球蛋白水平显著下降.
结论:
- 奥米克朗感染导致免疫和代谢障碍持续至少一年,两年后恢复不完全.
- 免疫失调和代谢变化之间的相互作用可能是COVID-19长期健康影响的基础.
- 监测淋巴细胞和代谢动态对于管理COVID-19后的情况至关重要.
更多相关视频
08:41Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
3.3K
10:25Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
Published on: June 5, 2021
5.2K
相关概念视频
Factors Affecting the Risk of Infection
13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K
Overview of Carbohydrate Metabolism
3.2K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
3.2K
Psychoneuroimmunology: Diabetes and Cancer
432
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
432
Factors Affecting Illness
5.0K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
5.0K
